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This shows that each version of a promoter, even if it seems highly similar to others, requires careful investigation of expression patterns as each small alteration can alter tissue specificity.
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Cellular mechanisms of drug resistance arise in the cancer cell itself due to either genetic or epigenetic alterations that can alter sensitivity of the drug.
Please be careful in altering the ingredients because a small alteration can change the name of the recipe.
As large number of genes are affected by epigenetic alterations in cancer they can alter splicing and the nature of the transcripts.
First, alterations of hippocampal activity can alter extinction learning (Corcoran et al., 2005; de Carvalho et al., 2013; Psotta et al., 2013).
While the need for a kinetic curve is only required once, it can become challenging when studying an experimental animal from birth to adulthood due to alterations in metabolism that can alter the kinetics of luciferin processing.
Splicing alterations in CLL specimens can alter the type of transcripts and thereby function of a large number of cellular proteins that may provide the cell with survival advantage.
Mutagenesis studies have shown that alterations of this loop can alter the relative affinity of PII for its receptors, and that a small deletion of the apex of the T-loop, removing residues 47−53 Δ47−533), eliminated the binding of PII to its receptors (16), yet this deletion did not alter the binding of ATP or α-ketoglutarate by PII (16).
Nonetheless, our demonstration that alterations in snRNP levels can alter exon 7 splicing in vitro suggests that the decrease in exon 7 splicing upon reduction of SMN protein levels is due, at least in part, to change in snRNP levels in the cell.
Anthropogenic habitat alteration creates novel environments that can alter selection pressures.
It is suggested that serotonin can modulate the activity of dopamine and an alteration in the serotonergic neurotransmission can alter dopamine-mediated behaviour [ 9, 10].
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