The phrase "alteration at specific" is not correct and does not convey a clear meaning in written English.
It may be intended to refer to changes made at particular points or instances, but it lacks clarity and completeness.
Example: "The alteration at specific intervals improved the overall performance of the system."
Alternatives: "change at particular" or "modification at certain".
Each of the currently known IDs was initially reported to be associated with molecular alterations at specific chromosomal loci.
We have applied high-density SNP-oligoarray to detect copy number alterations at specific chromosomal regions in chromophobe RCCs and ROs, which may mark the loci of genes involved in tumor development.
CEL files with raw chip intensity data were analyzed for copy number alterations at specific loci previously reported to be associated with ependymoma using segmentation algorithm in Partek Genomics Suite (v6.6).
This inhibition of the ubiquitin proteasome pathway likely alters protein turnover of transcription factors and histone-modifying enzymes and is associated with epigenetic alteration at a specific lysine residue (K9) of histone H3 (i.e. increased H3K9-ac and reduced H3K9-me2) as well as DNA hypomethylation (Oliva et al. 2009 ).
We expected that neonatal habenula lesion (NHL) caused behavioral alterations that were different from those induced by adult habenula lesion, and neurodevelopmentally-specific alterations (e.g. alterations presenting only at specific ages) in the brain areas such as the PFC and NAcc where monoamine neurons projects.
Extensive, but small, alterations in methylation at specific sites were observed in weight loss intervention studies, and several associations between methylation marks at birth and later life obesity were found.
Epigenome editing refers to the directed alteration of chromatin marks at specific genomic loci by using targeted EpiEffectors which comprise designed DNA recognition domains (zinc finger, TAL effector, or modified CRISPR/Cas9 complex) and catalytic domains from a chromatin-modifying enzyme.
Indeed, it was documented recently in tobacco that pathogen infestation caused both general genetic instability (due to increased somatic recombination) and alteration in cytosine methylation at specific loci in the infected plants, and both of which are heritable to successive biological generations [ 25, 26].
These data support the notion that persistent inflammatory conditions offer powerful chemical, biological and environmental hazards in causing additional genetic alterations at site-specific tissues.
Loss of function of proteins encoded by such genes is expected to result in alterations of epigenetic marks at specific genomic loci.
