The phrase "alteration at positions" is correct and usable in written English.
It can be used in contexts such as discussing changes in data, sequences, or specific locations within a text or structure.
Example: "The alteration at positions 5 and 10 significantly impacted the overall outcome of the experiment."
Alternatives: "changes at locations" or "modifications at points".
Amino acid comparison within this region among 1918NA, USSR77NA, Tex91NA, Kaw176NA and Duck80NA suggested that each alteration at positions 430, 432, 434, and 455 (USSR77 numberinging) or deletion at position 435 in the 1918 virus NA could determine the low-pH stability (Figure 3C).
Similarly, the substitutions of the hydroxyl and basic side chain in serine and lysine with aliphatic and an acidic amide side chain in glycine and glutamate in three isolates with different arrangement, suggest functional alteration at positions 234 and 235 on the enzyme, respectively.
Correspondingly, the effect of the threonine substitution at position 392 on CXCR4 binding was much more severe than that of alteration at position 393.
It involved an alteration at position 2685 (T>C) that resulted in a Tyr to His substitution at codon 856 (Y856H) in exon 11.
In addition, the alteration at position 150 (138 in H3) from Ala to Ser, which may affect the conformation of residues lining the receptor binding site, has also been linked to changes in receptor specificity in H1 viruses [38].
To determine whether the newly identified sequence alteration at position 78 (US56) was responsible for the 2.2-fold increase in P97 promoter activity, site directed mutagenesis was performed.
The mutations in ura3 -1, ura3 -p, and ura3 -e are the following: G to A at position 701 of URA3, G-to-A change at position 608, and T-to-A alteration at position 170, respectively.
We identified a novel BRCA1 mutation in two Jewish-non-Ashkenazi families with ovarian cancer: a thymidine to guanidine alteration at position 3053, resulting in substitution of tyrosine at codon 1017 for a stop codon (Tyr1017Ter).
Cx43 has been investigated in a HER2 model where investigators used genetically engineered mouse models to express a mutant form of Cx43 containing a glutamine to a serine alteration at position 60 (G60S) that localizes to gap junctions but has impaired gap junction intercellular communication [ 28].
These include hemoglobin C (HbC), which, like HbS, contains an alteration at position 6 in the β-globin chain but instead of valine, glutamate is replaced by lysine, as well as α-thalassemia, a quantitative hemoglobinopathy where carriers produce reduced amounts of the α-globin chain, leading to an excess of unpaired β-globin in their red blood cells (Taylor et al., 2013; Williams, 2006).
Although the residue alterations at positions 1512 1526 and at position 1530 had minor impact on toxin efficacy, the exchange of hydrophobic Ile at position 1529 in DmNav1 to the Lys present in rNav1.2 largely impaired the toxin-channel interaction.
