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From 1777 Vanbrugh's original was replaced on the stage by Sheridan's A Trip to Scarborough, a close adaptation but with some "covering", as the prologue explains, drawn over Vanbrugh's "too bare" wit: As change thus circulates throughout the nation, Some plays may justly call for alteration; At least to draw some slender covering o'er, That graceless wit which was too bare before.
It has been argued that although deamidation could be actually considered as a "structural alteration", at least in some instances, the persistence of such deamidation hot spots during evolution may otherwise serve to certain functions [5].
In this regard, it has been shown that an overexpression of AChE in transgenic mice produces progressive neurochemical, neuromorphological, and neurocognitive alteration, at least in spatial memory in adult mice (Andres et al. 1997, 1998; Beeri et al. 1997, 1998).
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A blank indicates that no significant alteration (fold change at least 1.5, p value ≤ 0.05) was observed.
The fold-changes for the various similar sample sets (e.g., exercised rodents) were averaged and a simple similarity scoring scheme applied based on the numbers of genes with same-direction alteration (fold change at least 1.5) between each pairwise disease condition comparison.
The concentrations of all examined parameters showed significant alterations at least 24 or 48 h after SIRT.
This means that segmental alterations, at least theoretically, can contribute to tumorigenesis but have fewer gene dosage effects than aneuploidy.
Surprisingly, decreased reelin expression and/or CPO exposure failed to induce measurable cortical alterations, at least in terms of cell populations expressing Dab1.
As a consequence of these metabolic alterations, at least 50%% of people with diabetes develop one or more microvascular (viz. retinopathy, neuropathy and nephropathy) or macrovascular (viz. myocardial infarction, heart failure and stroke) complications [ 2].
A final source of information is case studies from alterations at least partially analogous to dam removal, including breaching of beaver and debris dams, accidental human dam failures, and dam maintenance activities.
Lesions (percentage of animals with severe integument alterations – at least one lesion or swelling) were observed especially in the hock region, in the cows kept in THSNE, the difference between the two housing systems being significant (t = - 6.65, P < 0.001, df = 78).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com