The phrase "alteration at different" is not correct and does not convey a clear meaning in written English.
It seems to be an incomplete thought and lacks context to determine its intended use.
Example: "The alteration at different stages of the project was necessary for its success."
Alternatives: "changes at various" or "modifications at different".
An increasing number of investigations suggest pathophysiological alterations at different levels of the neuroaxis, either alone or simultaneously within the peripheral or central nervous system, in the etiopathogenesis of primary BMS.
These studies support the idea that alterations at different hierarchical levels in bone are induced by in vivo mechanical stimulation.
In most studies, a large number of experimental animals are required to assess lung alterations at different stages of the disease.
One of the major advantages of HRM is for the detection of somatic mutations in genes that can have alterations at different positions in the coding sequence.
The co-occurrence and mutual exclusivity of copy number alterations at different loci may also reflect co-operating and complementary cancer genes, respectively.
These results, although contradicted with the previous report that majority of the mutations involved in homoplasmy to homoplasmy changes, were consistent with random occurrence of mtDNA alterations at different times during tumorigenesis, or, mutations that might become homoplasmic at different rate.
Using these and our own markers (Table 1) we found two major alterations occurring at different evolutionary stages of diploid wheats.
In parallel, transcriptomic analysis of CBX2 expression revealed a strong bias towards CBX2 upregulation, although this alteration was observed at different stages among the various tumour types, indicating some context specificity in CBX2 activity and binding partners.
The alterations can occur at different levels: mutation, copy number variations or gene translocations resulting in altered expression of the corresponding genes or impaired protein functions.
Epigenetic alterations may occur at different stages of tumorigenesis and malignant progression [6], [7], but some researchers believe that aberrant methylation takes place before genetic alterations.
