d genetic alterations associated to the cell line.
Information on gene alterations associated to poorly differentiated (PDTC) and anaplastic thyroid carcinomas (ATC) is scarce.
Taken together, these data could be an important resource in understanding the epigenetic alterations associated to CRC.
We evaluated transcriptome alterations associated to DNA helical stress from the transcript ratios of the sir3 strains as above (top2 ts versus TOP2).
In the present study, we sought to explore the epigenetic alterations associated to grade II PXA and those occurring associated with the acquisition of histological malignant features, such as mitoses (as above mentioned) and/or necrosis.
In order to improve our knowledge of lung cancer biology in non-smokers, one of the first questions to answer is: what are the molecular alterations associated to EGFR mutations in lung cancer?
In the present study, we analyzed DNA hypermethylation on the promoter sequences of a panel of cancer-related genes in order to investigate epigenetic alterations associated to this process.
The identification of specific AM molecular signatures (cancer profiling) could be useful for precise tumour diagnosis and specific therapy design, distinguishing the different molecular alterations associated to different tissues.
Using WGBS of lymphoblastoid cell lines (LCLs) obtained from an ICF patient harboring mutated DNMT3B and one healthy control, we unraveled changes in DNA methylation at base-pair resolution and determined yet unknown alterations associated to the disease phenotype.
