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This finding is consistent with the hypothesis that alterations in gene expression that characterize the transition from active disease to remission may be accomplished alterations in chromatin accessibility through epigenetic alterations.
Such alterations can be accomplished using chemical treatment or genetic manipulation to introduce site specific mutations [ 13, 14].
We observe a similar result in our ovarian serous cancer samples; it is likely that deregulation of this pathway, while critical for tumorigenesis, can be accomplished through alteration of a single key molecule at which point selective pressure is relieved for altering other proteins involved in this signalling pathway.
Recent studies have revealed that modulation of both host and viral mRNA translation can be accomplished by selective alteration of translation factors in virus-infected cells.
Naturally omnivorous, Mr. Sharpton has always been a blender of unlikely elements (hair by James Brown, rhetoric by the Baptists) and now his blending will combine the advocate's megaphone with the anchor's teleprompter — a unique bit of alchemy that Mr. Sharpton says can be accomplished without an alteration of his message.
And, of course, alterations in consciousness can be accomplished by means of psychoactive -- even psychedelic drugs.
Assignment of the peaks to different compositional sequences was accomplished through systematic alterations in polyester composition.
One means by which alterations to chromatin structure is accomplished is through post-translational modifications (PTMs) of the histone proteins.
We here consider parallel evolution in a broad sense by assuming that not all characters are involved in the parallel evolution and by not assuming that evolutionary changes are accomplished by similar alterations in the developmental program (contra [ 2, 102]).
Yet this momentous alteration in the international equilibrium was accomplished so swiftly that foreign diplomats had barely begun to grasp its implications before the struggle for hegemony in Germany ended.
"All the meaningful social alterations of the past 20 years have been accomplished through the class action or a similar legal procedure".
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