Sentence examples for alter translational from inspiring English sources

Because eEF1A delivers aa-tRNA to the ribosome and cognate codon:anticodon interactions stimulate its GTPase activity, mutants of this factor could alter translational fidelity in two ways.

This hitherto unrecognised class of potentially functional variants we designated as 'STEPs' (Splice Translational Efficiency Polymorphisms) [15], a class of polymorphisms in non-coding RNA that may affect splicing such as to alter translational efficiency.

In another study, authors analyzed the ribosome footprint to mRNA ratios in meiosis and concluded that uORFs in differential ends could alter translational efficiency of mRNA.

On the other hand, recent evidence also suggests that synonymous mutations are able to alter translational efficiency of a gene and, therefore, might be pathogenic (Berleant et al., 2009).

However, it is difficult to design mRNA sequences for expression at targeted protein levels, since even a few nucleotide modifications around the start codon may alter translational efficiency and dramatically (up to 250-fold) change protein expression.

The role of the peptide exit tunnel is primarily to act as a route of egress for the nascent peptide; however, in some cases, specific interactions between the nascent peptide and the exit tunnel walls have been shown to alter translational regulation.

Examples of its application are also presented for analysis of the altered translational positioning and structural conformation of nucleosomes remodeled by the SWI/SNF complex.

Alternatively, altering translational efficiency by modifying the RBS strength or through codon optimization would also vertically scale the response curve.

Of the 1253 mRNAs that showed altered translational efficiency in response to DTT alone, 536 were down-regulated.

This study identified translational regulation of several mRNA targets important for cancer development, and suggested that altered translational control downstream of eIF4E hyperactivation may be required for AKT-driven cellular transformation.

Since the deletion constructs plucFTP-Δ2, plucFTP-Δ3 and plucFTP-Δ4 are probably not able to remove the leader intron, one could assume that the relative activity of the luciferase reporter could result from altered translational efficiency.