Sentence examples for alter this pathway from inspiring English sources

ALS-causing SOD1 mutations apparently alter this pathway by increasing exposure of buried epitopes in misfolded species populated at endpoint.

Despite multiple efforts to alter this pathway, the only neuroprotective measure that has profound effect on survival and functional outcome after CA is hypothermic [ 3, 4] or normothermic [ 5] targeted temperature control.

Moreover, because endocytosis still occurred in experiments where the dynamin phosphorylation state could not be altered, this pathway is likely not responsible for the calcium-dependent initiation of endocytosis (Gad et al., 1998).

Changes in microbial communities due to the presence of earthworm-worked material into unworked material may also alter this decomposition pathway indirectly, possibly by modifying the composition of the microbial communities involved in decomposition, thus probably affecting the decomposition rates [12].

Therefore to exclude the possibility that the changes in aberrant transcript are simply due to HDACi altering this degradation pathway, experiments were performed with a combination of HDACi and NMD blockade with a translational inhibitor, emetine to quantify the exon 11 skipped transcripts.

In all, 82.3% for CeO2, 80% for NAC and 87% for Sm-CeO2 of genes altered in this pathway had an opposite direction as compared to the untreated cells for all treatments, indicative of pathway inhibition.

Genes recurrently altered in this pathway include AR, ARNT, EP300, CREBBP, JAK2, JAK3 NOTCH2 NOTCH3, NOTCH3, and PARP1.

This demonstrates precisely how off-path reactions may alter the pathway enrichment structure.

These results suggest that splenic nerve-derived catecholamines regulate the egress of splenic monocytes during infection and that altering this pathway can alter survival during septic peritonitis in mice.

The fact that tumour development is so dramatically altered by regulating this pathway adds a novel level of complexity to a system where the precise balance between pro- and anti-angiogenic factors is of key importance.

In the meantime, SPAG5 downregulation can alter mTOR pathway activity.