It is likely that mutations at this interface alter the orientation of PR70 and the catalytic subunit, and thus distort precise orientation of the substrate at the active site.
Deletion of 1 or 3 amino acids in this β-sheet would alter the orientation of Cavβ with respect to α1 by 180°, while deletion of two would return the orientation back to WT (Fig. 7).
In comparison to supine positioning of the preoperative CT scan, the bolsters placed for appropriate positioning and padding may alter the orientation of the pelvis in space.
Binding of these compounds has been proposed to alter the orientation between domains of FtsZ and thus inhibit FtsZ activity.
We affirm that these results strongly support our hypothesis that the Bdel mutations alter the orientation of the β subunit with respect to the α1 subunit.
The third, P5, is predicted to alter the orientation of the binding site for YopJ such that it no longer efficiently modifies its substrate.
As a second test of the direct coupling hypothesis, we deleted 1, 2, or 3 amino acids in the middle of the linker in order to alter the orientation of AID-bound β subunit with respect to α1.
As the animals walked under open-loop conditions steering manoeuvres did not alter the orientation of the animals within the sound field so that sound stimuli were always perceived under identical acoustic conditions.
PPIases alter the orientation of peptide chains at proline residues, thereby aiding proper protein folding [ 20].
These may alter the orientation of the MT bound motors, resulting in the reversal of helical directionality during a processive run, as occasionally observed.
