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As such, alteration of BMSC function in response to elevated systemic mediators has the potential to alter their function in biologically relevant ways, including downstream alteration of cytokine production that influences hematopoietic development.
Our LESMD simulations suggest that alterations to the internal cavities as a result of the mutations alter their function rather than eliminate them.
Fortunately, most variant hemoglobins are not sufficiently affected to alter their function, and therefore no observable illness occurs.
After five years of work -- patient, brilliant, solitary work during which McClintock sometimes spent the fitful nights sleeping on a cot in her lab -- she was led to the unorthodox conclusion that genes are not fixed links in the chain of a chromosome, but instead can change positions, rearrange themselves, and in doing so alter their function.
Our increasing knowledge of tetraspanins and the pathologies that alter their function will undoubtedly inform the rational design of novel cancer therapies.
Airway epithelial cells are exposed to many agents present in the air that can alter their function and have important structural consequences for the airways.
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Such changes may propagate upward through the trophic structure of ecosystems to alter their functions and values, and those alterations may be more severe in terrestrial than in aquatic ecosystems.
Accordingly, drugs that specifically alter their functions display antineoplasic properties, and some of these drugs are already under clinical trials.
Under pathological conditions, excessive amounts of ROS induced by Cd can modify proteins, lipids and DNA, alter their functions, and activate related signaling pathways [10], [35], [38] [42].
It is important to note that these cell adhesion genes are generally large, providing more opportunities for allelic variants that could alter their functions in a number of fashions.
In addition to proteasomal degradation, the proteins obtain or alter their functions through mono- or polyubiquitination.
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