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From the viewpoint of evolution only those changes are important which alter the genotype but, since adaptive evolution cannot proceed without selection, these changes also have to alter the phenotype (otherwise they are neutral mutations).
From the biomechanical viewpoint, both bone variations and wedge sizes might alter the stabilizing effect of those HTO plates.
It aims, from the viewpoint of system biology, at the characterization and quantification of pooled biological molecules that transmit external signals to alter the structure, function, and dynamics of an organism or organisms.
This viewpoint simply reflects the more obvious impact of nsSNPs on coding regions than regulatory regions: the substitutions tend to alter the amino acid sequences of the proteins.
Alter the game settings.
Alter the stressor.
Alter the dress.
Alter the voice.
Alter the toe caps.
Do not alter the height.
Alter the way you play.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com