The phrase "alter the specificity" is correct and usable in written English.
It can be used when discussing changes to the level of detail or precision in a particular context, such as scientific research or technical writing.
Example: "To improve the accuracy of our results, we need to alter the specificity of our measurements."
Alternatives: "change the precision" or "modify the detail level."
A second series of reporters, activated by human rhinovirus 3C protease, demonstrated that we could alter the specificity of the reporter by reengineering the protease recognition sequence.
I am also using a cell-based functional assay to test whether I can alter the specificity of particular types of clustered protocadherins by introducing mutations into the interaction interface.
Variations in N-CAM activity thus do not occur by changes in the amino acid sequence that alter the specificity of binding.
Any modification in the targeted proteins could indeed alter the specificity and sensitivity of the assay.
Conversely, ORC-binding could alter the specificity of Hat1p to modify substrates different from free histone H4.
The GYT → TFV replacement in ALX SH2 domain did not alter the specificity towards the selected phosphopeptides.
Modification in the structure of SAHA altered the specificity of 'δ ' towards a specific HDAC enzyme[83].
A PBP added to an in vitro assay altered the specificity of a moth pheromone receptor, making its response more specific [31].
The flexibility of the described design allows for sensor specificity change through altering the specificity of the aptamer.
Altering the specificity of DNA-cleaving enzymes could be useful in many medical or biotechnological applications, but it is quite a challenge in terms of computational protein design.
Appropriate conditions were, thus, identified for coupling AMB8LK Fab' fragment to cationic emulsion without altering the specificity and affinity of the Mab fragment to the tumor antigen.
