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Since this domain regulates its DNA binding specificity, it is possible that this phosphorylation event could alter the specific genes that are transcribed upon different extracellular signals, which is consistent with other transcription factors [56].
One can therefore experimentally alter the specific binding site or its competing sites, as well as the transcription factor, by point mutations and then observe the effect on specificity, e.g. by measuring the expression of upstream genes.
These results argue that DGCR8 phosphorylation does not significantly alter the specific processing activity of individual minimal MCs into which DGCR8 is incorporated.
Nevertheless, owners should be educated to observe, and then avoid or alter, the specific situations in which they see their dog's condition worsen [ 1 ].
Hence, it represents a comparison treatment that offers the control participants a proven treatment, which does not aim to alter the specific target symptoms which are addressed in MBT.
Variations in d would alter the specific values produced by the power calculations, but crucially do not alter the inferences made when comparing the relative values across sequences or profiles.
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And it states that "unilateral decisions and actions altering the specific character and status of Jerusalem are morally and legally unacceptable," addressing one of the most sensitive issues between Israel and the Palestinians.
It was observed that yqhD expression in L. reuteri, altered the specific substrate uptake, product and byproduct formation rates significantly (Figure 5).
Compound specific isotopic analysis of amino acids shows that (1) labeling of all amino acids in both carbon and nitrogen is derived from the original plant carbon and nitrogen, but (2) microbes have completely altered the specific δ13C values.
Therefore, it provides a simple and label-free approach to detect ions with high sensitivity and specificity, and promises to provide a solid sensing platform for the detection of targets by altering the specific sequence of nucleic acid probe.
Altering the specific pathways of aggregation is a potential therapeutic strategy which may not decrease the total amount of aggregation but could decrease neurotoxicity.
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