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These changes may alter the signalling from neurons to the vasculature and, in consequence, the relationship between neuronal activity and the BOLD signal.
This binding may allow the hijacking of host protein binding sites from their usual binding partners and thus alter the signalling pathways of the host cell.
However, it remains to be tested as to whether these mutations alter the signalling properties of Gab1, and so it is unclear at this stage whether they represent real drivers or merely passengers of tumourigenesis.
This seems to alter the signalling function of the receptor, thereby predisposing carriers to disease [ 38].
In addition, BMPR complexes are believed to be internalised by the cell in processes which both alter the signalling dynamic and lead to loss of or attenuation of activation [ 34- 38].
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Butcher continues to look at the interplay of the different stages of trafficking, with an eye toward how to alter the signals.
Note that applying this model does not alter the signal processing part of the simulation tool.
Also, we could alter the signal generation process to take into account this effect.
This will not alter the signal-to-noise ratio (SNR) but will assist theoretical derivations.
All variables tested alter the signal to noise ratio of the assay.
Proteolytic processing can significantly alter the signaling activity of chemokines and is most likely one of the major regulatory mechanisms for chemokines.
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