Sentence examples for alter the selectivity from inspiring English sources

This also provides deeper insights into how single-site mutations can alter the selectivity profile of closely related ligands against a target protein.

We find that even though the drug interactions correlate between the two species, cell-type-specific differences in drug interactions are common and can dramatically alter the selectivity of compounds when applied in combination vs. single-drug activity enhancing, diminishing, or inverting therapeutic windows.

We anticipated that, embedding the acid groups into polymeric analogs of desirable solvents, via noncovalent interactions with the reaction participants, the surrounded solvent mimic environment may be able to affect the acid catalyzed reaction rate or alter the selectivity of product formation.

These results show that varying the properties of γ-Al2O3 support can alter the selectivity of CO2 hydrogenation, moreover, the presence and number of low-coordinated Pd particles is of great importance to improve the overall activity and selectivity of CO2 hydrogenation.

An analysis of P3 to P4' residues of the RSLs of various substrates like binding serine protease inhibitors such as for subtilisin, thrombin, trypsin, chymotrypsin and furin was performed to identify the minimum side chains of CrSPI-1-D1 to be mutated to alter the selectivity (Table 2).

However, site-directed mutagenesis work, thus far, has not positively identified residues that alter the selectivity of these proteins (data not shown).

Adjacent co-adsorbed water molecules participate in the transition state of formate decomposition, accelerating the formate turnover rate and altering the selectivity to favor dehydrogenation.

From these results the authors propose a model of PAR1 activation involving the interaction of PAR1 with PAR3, which alters the selectivity of PAR1 for G13 coupling and finally promotes endothelial barrier dysfunction.

The latter finding indicates that these mec-10 mutations alter the ionic selectivity of the transduction channel in vivo.

Seeding does not alter the product selectivity to CO and H2 except at low conversion.

Amino acid substitutions of Subdued alter the ion selectivity and kinetic properties of the CaCC channels heterologously expressed in HEK 293T cells.