The phrase "alter the safety" is correct and usable in written English.
It can be used in contexts where changes to safety measures, protocols, or conditions are being discussed.
Example: "The engineers decided to alter the safety measures in response to the recent incident."
Alternatives: "modify the safety" or "change the safety".
Variation in design can indeed change the possible hazards incurred in each product, their causes, and can alter the safety requirements placed on individual components in different SPL products.
If eGFR is calculated annually (and more frequently in those at high risk for deterioration in renal function), it is unlikely that patients will experience changes in their eGFR levels large enough to rapidly alter the safety of metformin therapy.
This finding is consistent with prior studies, which demonstrated that the addition of cytotoxic chemotherapy did not significantly alter the safety profile of other tyrosine kinase inhibitors including sorafenib (Richly et al, 2006) and vandetanib (Heymach et al, 2007).
The results of this study support the view that a single high dose of rFVIIa offers a viable and effective alternative to standard dosing without altering the safety profile.
While the likelihood of altering the safety of transgenic crops through DNA-insertional effects may be lower than for traditional breeding [ 16, 18, 20, 22, 39], the safety assessment for new transgenic crops bearing traits intended to alter endogenous metabolic pathways may be aided by hypothesis-driven compositional analyses.
Results of this study suggest that the addition of benzyl alcohol to the formulation of the sterile injectable has the potential to reduce wastage by allowing a shelf-life of up to 28 days after the initial withdrawal/needle penetration without altering the safety or efficacy of the preparation.
Biotherapeutics can elicit immune responses, which can alter the exposure, safety, and efficacy of the therapeutics.
In addition to vitamins and herbs, says Dr. Seres, supplements can include hormones and other pharmacologically active ingredients that can alter the efficacy and safety of medications and affect the body's physiologic functions.
Although they provided useful information about the long-term outcomes and the nature of the disease, they did not alter the conclusions about safety and efficacy from the randomized portion of the trial.
The presence of impurities that are different or at different levels from those in the reference product can also provoke undesirable immune responses, which may alter the efficacy and safety profile of the biological drug 11.
In the mid-1990s, Congress fundamentally altered the public safety net when it passed the Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA) of 1996, otherwise known as welfare reform.
