Sentence examples for alter the proliferative from inspiring English sources

In addition, we demonstrated that complexity of ECM from bECM and MaxGel does not affect cell viability, does not alter the proliferative capacity of glial cells, and does not affect the astrocytic phenotype in long-term cultures.

Collectively, the data indicate that ECM coatings (i.e., bECM and MaxGel) are not required to maintain cell viability, do not alter the proliferative capacity of glial cells, and do not affect the astrocytic phenotype in long-term cultures.

This study was designed to test the hypothesis that growth factors (basic fibroblast growth factor (bFGF) and hepatocyte growth factor/scatter factor (HGF/SF)) used to alter the proliferative and migratory state of cells can alter plasmid DNA uptake and expression.

The lack of PSA NCAM on the surface of migrating precursors might alter the proliferative properties of this glial cell population, a scenario that appears reminiscent of astrogliosis occurring in neurodegenerative diseases even before any signs of neuronal damage.

In addition to growth factors, ECM proteins can alter the proliferative response of luminal MECs [23].

Although ectopic expression of human PARM-1 in a prostate cancer cell line results in increased colony formation [15], suggesting a probable role of PARM-1 in cell proliferation, the others reported that transient expression of rat PARM-1 does not alter the proliferative property of another prostate cancer cell line [16].

We then tested whether gene transfer via rAAV altered the proliferative, matrix biosynthetic, and chondrogenic activities in bone marrow aspirates maintained over time in dynamic and static culture conditions while evaluating the possible effects of candidate sox9 gene transfer on these processes using this vector class.

We determined whether transfection was altering the proliferative potential of the cells by H-thymidine incorporation.

We also assessed the role of CD6 in untransfected ex vivo T cells interacting with APCs, by testing whether blocking the CD6 CD166 interaction altered the proliferative behavior of the T cells.

Since IPF is a fibroproliferative disease, and the level of proliferative capacity of activated fibroblasts may be increased in IPF patients [ 40], we sought to determine whether abnormal plakoglobin expression altered the proliferative response to PDGF or TGF-β in normal and IPF fibroblasts.

While the results of pMTH1-U937 cells are in agreement with those of TPA-induced wild-type U937 cells [ 13], these findings suggested that down-modulation of the CD11b integrin significantly altered the proliferative and differentiation capacity of the cells associated with marked intra- and extracellular metabolic changes.