Sentence examples for alter the potency of from inspiring English sources

While this may not alter the potency of the NK1 antagonists that have good blood-brain barrier permeability, it may increase the penetration of those NK1 antagonists that normally would not permeate an intact blood-brain barrier to the same degree.

Previously the STK15 (rs2273535, p.Phe31Ile) variant was found to alter the potency of STK15 transformation [27] and was reported to be associated with cancer risk in a number of cancer types including ovarian, colorectal, breast, oesophagus and lung [28] [31].

Importantly, cyanamide did not alter the potency of the NO donor Sper/NO, ruling out non-specific effects of this inhibitor on NO bioactivity.

Overexpression of the L. major nitroreductase did not alter the potency of (R)- or (S -PA-824 againS -PA-824ovani promaS -PA-824

As concurrent treatment of DEX (10 n M) failed to alter the potency of docetaxel, we conducted a further series of experiments examining the effect of pre-treating PC3 cells with DEX before docetaxel administration.

Together, these data show that fluctuations in DAT levels alter the potency of releasers and MPH but not blockers and suggest an integral role of the DAT in the addictive potential of AMPH and related compounds.

However, H547A-hDAT did not alter the potencies of DA and GBR12909 for inhibiting DA uptake.

We determined whether H547P, H547R, and H547D differentially alter the potencies of DA, cocaine, and GBR12909 for inhibition of [3H]DA uptake (Table 2).

There has been considerable debate in the literature as to how variability in dopamine transporter (DAT) levels alter the potencies of psychostimulant drugs.

Structural changes of local anesthetic molecules can alter the potency to inhibit NMDA receptor signaling and are independent of the local anesthetic (sodium-channel blocking) potency.

Furthermore, intrapeptide F deletion alone differentially altered the potency of CK2 action towards its different classes of cellular targets.