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About the mechanism underlying pi-dependent up-regulation of Runx2 by Klf5, we speculate that high Pi might alter the modification of Klf5 or its interaction with other cofactors, subsequently leading to increase in Klf5 binding to the Runx2 promoter.
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Mutations repressing or enhancing Wolbachia action in males will alter the modification-function of Wolbachia accordingly, while in females such mutations may similarly alter Wolbachia transmission-rates (and thereby indirectly the rescue-function of Wolbachia) or change the rescue-function directly without affecting transmission.
The pore size reduction can be tuned by altering the modification circumstances.
It is important that if HbA1c units are altered, the modification should be coordinated so that it is instituted throughout the entire country to avoid having different units used in a single country.
To improve the efficiency of reprogramming, numerous factors or molecules have been used to alter the epigenetic modification in somatic cells or reconstructed embryos.
The ability to alter the epigenetic modification and expression of SHANK3 by environmental factors suggests that SHANK3 may be a valuable biomarker for dissecting the role of gene and environment interaction in the etiology of ASD.
As an alternative approach to the study of the influence of heterochromatin in cohesin recruitment, we used drugs that alter the histone modification or the DNA methylation profile of chromatin.
45– 47 Therefore, the sitagliptin-induced improvement in postprandial hyperglycemia may alter the posttranslational modification of adiponectin.
In contrast, binding of XerC and XerD to pseudo-HJs did not alter the chemical modification pattern of KMnO4.
Most of these processes seem to alter the post-translational modification of Drp1, including its phosphorylation [65], ubiquitinylation [66] and sumoylation [67], [68].
Therefore, we investigated whether exercise would alter the O-GlcNAc modification of mSin3A, a transcription factor that is directly involved in hypertrophic signaling.
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