Sentence examples for alter the malignant from inspiring English sources
A new molecular signaling paradigm has been described in the last decade, offering more potential therapeutic targets to alter the malignant phenotype of this disease.
Although the underlying mode of action has not been explored in these studies, the data clearly indicate that VPA may alter the malignant behaviour of tumours that do not respond to chemotherapy.
In our study, the moderate decreases in E6/E7 mRNA and protein expression also partially altered the malignant characteristics.
Previous reports have indicated that reprogramming technologies may be useful for altering the malignant phenotype of cancer cells.
It is intriguing to speculate whether manipulation of NAV3, the only other gene that displayed both properties of differential connectivity and differential expression across tissue grade, would have similar effects in altering the malignant potential of breast cancers.
Over the last decade, it has become known that hypoxia changes the pattern of gene expression that alters the malignant potential of tumours leading to more aggressive survival traits, as a result of which cancer cells become difficult to treat by radiation and chemotherapy [ 2].
It employs using genetic modification to alter the sensitivity of malignant or normal tissue to the effect of radiation [14 17].
CpG ODN also alter the phenotype of target malignant B cells as indicated by upregulation of MHC, immunostimulatory molecules, and antigens that serve as targets for other approaches to lymphoma immunotherapy such as CD20.
We have found that telomerase inhibition per se does not alter the sensitivity of several malignant cell lines to any of the drugs tested.
At the same time, controversies arose, based on a study in 37 patients suggesting that this antiangiogenic drug may alter the recurrence pattern of malignant gliomas (Norden et al, 2008).
Clinical studies have also shown that bevacizumab may alter the recurrence pattern of malignant gliomas by suppressing contrast-enhancing tumours more effectively than non-enhancing, infiltrative tumours [ 22, 70].
