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Pregnancy can alter the immune reactions and auto-immunity in case of chronic lymphoid leukemias [ 11].
Virological status is known to impact on immunity: chronic infection by these pathogens may alter the immune system and lead to consequences (immunosenescence) similar to those induced by aging directly (van Baarle et al 2005; Koch et al 2006).
Some infections can cause permanent damage to body tissues, or alter the immune system, in ways that leave people more at risk of medical problems when they are older.
Medawar's work resulted in a shift of emphasis in the science of immunology from one that assumed a fully developed immune mechanism to one that attempts to alter the immune mechanism itself, as in the attempt to suppress the body's rejection of organ transplants.
Oil products are known to injure the lungs and alter the immune function of mammals, leading to an increased susceptibility to pneumonia.
Because the Th1/Th2 imbalance could promote the progression of allergy or infection [66], our results partly explained that TiO2 NPs may impair balance of Th1 and Th2 cytokines and alter the immune response toward the allergy-related Th2 cytokines.
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Indeed, these transient early modifications could also alter the immune-reactivity towards infections later in life [ 45].
Recent studies have demonstrated cellular uptake of HDP and IDR peptides by using biotinylated peptides and have shown that C-terminal cysteine modification and biotinylation does not alter the immune-modulatory activity of these peptides [ 29, 43].
This may have to do with how pregnancy alters the immune system.
Rob O. said the novelty of TGN1412 never came up in upbeat pretrial briefings, adding, "I had no idea it altered the immune system".
Manipulation of metabolic programs at an early stage may offer therapeutic opportunities for altering the immune responses in diseases.
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