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There are two main types of reactions [8]: construction reactions, which create new carbon carbon bonds in the target's skeleton, and functionalization reactions, which alter the functional groups attached to the skeleton but do not alter the skeleton itself.
We identified 30 human-specific "fixed" amino acid substitutions/indels including two amino acid substitutions that potentially alter the functional roles of their genes as candidate sites responsible for human-specific brain function.
Even something as fundamental as being left-handed can alter the functional organisation of the brain.
Exposure to heat can modify labile milk components and alter the functional properties of milk proteins.
Protein engineers traditionally rely on amino acid substitutions to alter the functional properties of biomacromolecules, yet have largely overlooked the potential benefits of reorganizing the polypeptide chain of a protein by circular permutation (CP).
We suggest that, in a similar manner, the changed mechanical properties of mutated BR alter the functional energy landscape favoring different reaction pathways in the light-induced proton pumping mechanism.
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Such modifications could, through increased calcium binding potential or altering the functional C-terminal extension, also have impact on the biological function of the protein when localized in the particular compartments.
Were any one of these parts to be altered, the functional integrity of the whole would be destroyed.
Owing to large standard errors, the coefficients on intermarriage are no longer significant in the second stage.20 Nevertheless, even upon altering the functional form of the estimation strategy, the direction of our results remains the same.
To address this endogeneity issue by using an instrumental variable approach, it is necessary to show that altering the functional form of the estimation model does not affect the empirical results.
The changes in the landscape structure with LULC changes have altered the functional abilities of an ecosystem evident from lowered hydrological yield, disappearing perennial streams, higher instances of human animal conflicts, declined ecosystem goods, etc.
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