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Importantly, perturbations to the experimental system via mutation are used to alter the corresponding valve setting(s).
For the v-vesicles that bound, native α-Syn had little effect on the efficiency (defined as the number of fusion events per docked v-vesicles) and the kinetics of Ca2+-triggered fusion upon injection of 500 μM Ca2+, and it did not alter the corresponding cumulative fusion distribution plot.
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We also synthesized and tested variants of 3p05p (Figure 5A) in which we eliminated the three mismatches by altering the corresponding nucleotides on the opposite half of the stem (NoMMp), or in which we retained the three mismatches but changed each of the two new pyrimidines in 3p05p to a different pyrimidine and the new purine to a different purine (3Mp).
Consensus voting occurred if there was a recommendation to alter the treatment plan; corresponding modifications to the treatment plan were discussed with the study participant and implemented.
In these cases, the total inactivation of the splice site is unlikely, although these changes could alter the splicing of corresponding exon, creating cryptic sites, thus producing a longer protein.
MacArthur's team then winnowed the list by removing errors and genetic mistakes that don't alter the function of the corresponding protein.
The abnormal transcript levels of the cluster 1/42AB in the cuff mutant are expected to impact the piRNA population and alter the production of the corresponding piRNA complement.
In our study, genus-specific and locus-specific indels were discovered in coding regions, which would alter the length of the corresponding amino acid sequences.
Importantly, BIM did not alter the labeling pattern of the corresponding L78A mutants.
Recently, we elaborated a series of dNTP pol substrate analogues in which the β,γ-bridging O is replaced by CXY moieties that alter the stereoelectronic properties of the corresponding bisphosphonate (BP) leaving group.
If the nsSNPs with a ≥5% minor allele frequency listed in Table III do indeed alter the phosphorylation state of the corresponding proteins, they then represent important candidates for disease susceptibility studies, especially relating to cancer risk.
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