alter the binding

USAGE SUMMARY

The phrase "alter the binding" is correct and usable in written English.
It can be used in contexts related to changing or modifying a connection, agreement, or physical binding of materials. Example: "In order to improve the document's durability, we need to alter the binding to a more robust option."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

It has been shown that GAGs can alter the binding with selectins because the latter bind several glycoproteins [ 53].

Arthritis Research and Therapy

FcγIIa and FcγIIIa possess polymorphisms that alter the binding of natural IgGs to those receptors.

Therapeutic Antibody Engineering Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

Substituting SRC-1 with Adnectin-1 does not alter the binding conformation of Compound-1 in the ligand binding pocket.

Journal of Molecular Biology

As opposed to heparin, LMWLs significantly alter the binding of the active site fluorescent ligand p-aminobenzamidine.

Thrombosis Research

Finally, we also simulated the ternary system with the full sequence of WW domain (all 46 residues) to see how the appended terminal residues alter the binding competition (see Fig. 3S for more details).

Nature

Importantly, our results demonstrate that H547A-hDAT displays increased Km value for DA uptake relative to WT hDAT, indicating that mutating the His547 residue may alter the binding site of substrate DA.

Nature

Similarly, mutation of threonine 168 to either valine or glutamate did not significantly alter the binding affinity of a catalytically inactive XCL100 protein for active p42 MAPK in vivo.

Stanford University

A fourth mAb with a longer CDR2 loop was not affected by mutation of residue 57, indicating that CDR2 domain length may alter the binding interface and lead to the involvement of other residues in protein A binding.

Journal of Chromatography A

Notably, our results suggest that the modification of the N-capping region could alter the binding specificity of PACAP without altering its biological activity, thereby opening the way for the design of more selective compounds.

European Journal of Medicinal Chemistry

Resistance to these drugs can emerge due to a variety of reasons including genetic or epigenetic changes which alter the binding site of the drug target, cellular metabolism or export mechanisms.

Journal of Theoretical Biology

Optimization of the palindrome did not significantly alter the binding of the initial TtgR dimer to the operator, but increased the cooperativity of binding and consequently the overall affinity.

Journal of Molecular Biology

Expert writing Tips

Best practice

When using "alter the binding" in scientific writing, clearly specify what is being bound and what factors are causing the alteration. For example: "Increased temperature can alter the binding of the enzyme to its substrate."

Common error

Avoid using "alter the binding" without specifying the subject of the phrase. Instead of saying "the mutation can alter the binding", specify "the mutation can alter the binding of the protein to the DNA."

Linguistic Context

The phrase "alter the binding" functions as a verb phrase, typically used as part of a larger clause. It describes the action of changing or modifying the way two or more entities connect or interact. Ludwig AI indicates its grammatical correctness and common usage.

Expression frequency: Very common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, "alter the binding" is a grammatically correct and frequently used verb phrase, primarily found in scientific contexts. Ludwig AI confirms its usability. It conveys the action of modifying how entities connect or interact, especially in molecular or chemical contexts. When using this phrase, ensure clarity by specifying what is being bound and the factors causing the alteration. Alternative phrases include "modify the bond" and "change the interaction". The phrase maintains a formal and scientific register, appearing most often in science journals and academic papers.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

modify the bond

This alternative focuses on changing a specific bond or connection.

change the interaction

This alternative uses a more general term, "interaction", rather than "binding".

adjust the association

This alternative uses "association" to refer to the relationship being changed.

influence the attachment

This alternative uses "attachment", suggesting a physical connection is affected.

affect the joining

This alternative replaces "binding" with "joining", implying a change in how things come together.

reshape the linkage

This alternative uses "linkage", emphasizing the connections between elements.

vary the adherence

This alternative uses "adherence", highlighting a change in how closely things stick together.

transform the connection

This alternative emphasizes a substantial change in the connection.

regulate the adhesion

This alternative suggests controlling the process of sticking together.

modulate the affinity

This alternative focuses on changing the strength of attraction or connection.

FAQs

How can I use "alter the binding" in a sentence?

You can use "alter the binding" to describe how something changes the way two or more things connect or interact, especially in scientific contexts. For example, "The drug may "modify the binding" affinity of the receptor".

What is a good substitute for "alter the binding"?

Depending on the specific context, you might use phrases such as "modify the bond", "change the interaction", or "adjust the association".

In what context is it appropriate to use "alter the binding"?

"Alter the binding" is generally used in scientific or technical contexts to describe changes in the way molecules or other entities interact. It's common in fields like chemistry, biology, and pharmacology.

How does "alter the binding" differ from "affect the binding"?

While both phrases suggest a change in binding, "affect the binding" is broader and could imply a more general influence. "Alter the binding" suggests a more direct and specific change to the binding process itself.