The phrase "alter the affinity of" is correct and usable in written English.
It can be used in contexts related to chemistry, biology, or any field discussing interactions between substances or entities.
Example: "The new compound was designed to alter the affinity of the enzyme for its substrate, enhancing the reaction rate."
Alternatives: "change the binding strength of" or "modify the attraction of".
Thus, the chemical modifications (the addition of a spacer, a chelator and Ga) did not alter the affinity of R824 to its target, i.e. the PS.
The results showed that the modification of the aptamer does not significantly alter the affinity of the aptamer for the antibiotic.
Furthermore, the cysteine at VL85 of ds-FV57 was mutated to serine to construct ds-FV57VL85Ser in order to avoid potential mis-formed disulfide bonds which would alter the affinity of the scFv.
On the other hand, the E406A mutation did not significantly alter the affinity of the three inhibitors (Table 3).
In one study, primate SNPs (rather than fixed differences) in the CCR5 promoter were shown alter the affinity of the transcription factor NF-κB for its cognate DNA motif and have a modest effect upon basal levels of CCR5 transcription [30].
Signals can also be transferred "inside-out" when cytoplasmic agonists alter the affinity of CAMs for certain ligands [reviewed by [ 45].
Effectors include myosin II for inducing tension, calpain to cleave talin and other adhesion components, and phosphorylation events that alter the affinities of different adhesion components (8).
In an effort to optimise the targeting and therapeutic efficacy of ALM, we hypothesise that strategies to alter the affinity for either one or both of the arms for their target antigens can be used to increase the window of selective targeting achievable with bs-scFvs targeting ErbB2'+'/ErbB3'+' tumours although not impairing the overall tumour retention.
This is likely to reflect a structural change in the DR molecule which alters the affinity of binding of the DRβ chain specific monoclonal antibody while the DRα chain specific mAb remains unaffected.
The second, highly charged 5R tag only slightly altered the affinity of the enzyme for its substrate.
ISRIB could be altering the affinity of phospho-eIF2α for eIF2B or overcoming the nonproductive interaction that blocks GTP loading, mimicking the effect of these mutations.
