Sentence examples for alter specificity from inspiring English sources

Our data identify effects of a specific protein partner on PUF-RNA interactions, reveal subsets of target sites not previously detected, and demonstrate that designer PUF proteins can precisely alter specificity.

CONCLUSIONS: These results suggest that the scope of directed evolution is substantially larger than previously envisioned in that it is possible to perturb the active site residues themselves as well as surrounding loops to alter specificity.

However, changes in domain partners can also alter specificity.

Some rare SNPs might alter specificity and remained rare due to purifying selection.

In order to enhance or alter specificity transcription factors often pair with other transcription factors or transcription coactivators.

The addition of these four nucleotides may alter specificity, resulting in amplification of the greater numbers of distinct trap haplotypes observed in both birds.

Restoration is restricted to the domains of endogenous dpp expression, despite ubiquitous expression of altered specificity EXD.

The degree of modulation can range from relaxed DNA specificity to almost completely altered specificity.

In sharp contrast, mutants of Asp167 showed considerably altered specificity profiles.

However, functional screening in human monocyte-derived macrophages using the xCELLigence label-free platform demonstrated altered specificity of our ligands.

Strategies for increasing affinity, altering specificity, creating broad-spectrum binding, and building novel enzymes from scratch are described.