Sentence examples for alter receptor function from inspiring English sources

Genetic variations in codons 16 and 27 of the human β2-adrenergic receptor (β2-AR) alter receptor function in vitro and are associated with various asthma-related phenotypes, including asthma severity and AHR.

Mutations of the first two residues within this motif usually alter receptor function and, when they occur naturally, can even cause diseases.

While any of these SNPs could potentially impact TAS2R expression or function, and therefore glucose and insulin homeostasis, we reasoned that the TAS2R9 variant was the most likely to significantly alter receptor function.

To date, one dozen polymorphisms have been identified in P2RX7, which alter receptor function [ 30, 31].

Inverse agonists include many compounds that were originally classified as antagonists, ligands that occupy the orthosteric binding site, but do not alter receptor function.

However, our knowledge about how the autoantibodies alter receptor function and how these effects possibly contribute to the pathogenesis and the clinical phenotype of chronic heart failure is still very limited.

Pike, L. J. & Casey, L. Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking.

The G>A polymorphism of the HCRTR1 gene leads to an aminoacid substitution of isoleucine at position 408 by valine, which could engender an altered receptor function.

The majority of these variations altered receptor function.

Similarly, a change in the LH to testosterone ratio may be indicative of altered receptor function or steroid synthesis.

These results suggest that ER phosphorylation alters receptor function (promoter targeting, chromatin remodeling and transcriptional output) effecting changes that could lead to a more sensitive response to EGF stimuli, as reported for tamoxifen-resistant breast tumors [43], [44].