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In contrast, there is a very low fraction of OMIDIs (0.26%, 4/1526) and nonsense mutations (0.13%, 2/1526) in EGFR singlets, consistent with a strong selection for mutations that alter, rather than delete, function.
The frequency of OMIDI pairs in the EGFR gene is approximately 10-fold greater than in the TP53 gene (and the one OMIDI pair in the TP53 gene does not result in a net in-frame mutation), reflecting the more frequent selection of mutations that alter, rather than delete, EGFR protein function.
The goal is to alter rather than inhibit transcription.
Similar(57)
The curved lens introduced a subtle bend to the lines, thus altering rather than recording reality.
In relying on this term, Rorty intends to appropriate Gadamer's description of understanding as a fusion of horizons, as an event in which the subject is altered, rather than a process over which she exerts methodological control.
We have analyzed Pho4 binding at UASp2 in a UASp1 asf1Δ mutant to address the possibility that nucleosome N-2 is altered rather than removed in asf1Δ cells upon PHO5 induction.
It is notable that the eight EGFR doublets containing OMIDI pairs all have closely spaced mutations that result in a net in-frame mutation, thus producing an EGFR protein with potentially altered, rather than absent, function.
The role of GCAP1 in controlling cyclic nucleotide levels in photoreceptors has largely been elucidated using knock-out mice, but the disease pathology in these mice cannot be extrapolated directly to COD3 as this involves altered, rather than loss of, GCAP1 function.
It is also possible that other gene(s) located at 16q are altered, rather than E-cadherin.
In contrast, cyclic introduction of estrogen may improve survival rate by continually altering, rather than unilaterally shifting, toward an ER- population.
Genomic instability is usually measured as the proportion of the genome that is altered rather than the number or patterns of those changes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com