Exact(2)
Achieving consistent densities between experiments may be challenging and entry into stationary phase may alter pathway activity (SI Figure S5).
This is consistent with a scenario in which deleterious changes are strongly purged from rate-limiting enzymes, because they alter pathway flux, but such changes may accumulate in enzymes with less control over flux (Mannakee and Gutenkunst, manuscript submitted).
Similar(6)
NEK2A has been shown to alter pathways like AKT and be activated by MAPK, as discussed previously.
This experimental approach allowed the intra- and extra-mitochondrial localization of metabolites, along with determinations of altered pathway flux.
The most significantly altered pathway involved genes associated with Wnt/β-catenin signalling, a pathway that regulates cell proliferation, differentiation and stem cell renewal [25].
In our metabolic pathway analysis, sphingolipid metabolism was the top altered pathway in lung cancer.
The pathway analysis indicated that sphingolipid metabolism was the top altered pathway in lung cancer.
P53 was the most frequently altered pathway in HBV-related HCC (47%, p=0.001).
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