Sentence examples for alter marks from inspiring English sources

Epigenetic research has long been hindered by the lack of experimental methods that would allow the targeted manipulation of chromatin marks in living cells, since mutational approaches and pharmacological inhibition alter marks globally and nonspecifically.

Future work is needed to establish baseline norms for epigenetic marks, to establish whether specific environmental exposures alter such marks, to determine whether WBC DNA methylation changes correlate with target tissue changes, and finally, to determine whether such changes are part of the causal pathway between environment and disease.

More relevant to our study, the isoflavone genistein has been shown to alter epigenetic marks in a model of adult-onset obesity [31], the yellow agouti Avy mouse, whose coat color and adiposity are dependant on the methylation state of an intracisternal A particle (IAP) retrotransposon inserted upstream of the Agouti gene [32], [33], [34].

Lead is among the most prevalent of toxic environmental metals, has substantial oxidative properties, and could also alter epigenetic marks after long-term exposure.

Moreover, Argonaute-dependent processes have been documented to alter chromatin marks and also the dynamics of RNA polymerase II was shown to be affected by Argonaute and Dicer [ 22].

Epigenetic mechanisms mediate the interaction between gene and environment throughout the lifespan; while the underlying genetic sequence does not change, environmental influences can alter epigenetic marks and thus alter gene expression and induce long-term changes in phenotype and disease susceptibility [ 9].

We therefore wondered whether NF-Y removal would alter this mark from these negatively regulated locations.

Predation pressure is known to alter scent marking (Roberts et al. 2001; Hughes and Banks 2010; Sunyer et al. 2013), defecation behavior (Boonstra et al. 1996), and strategies to camouflage nest sides (Mironov 1990).

Another report on the analysis of the phenotype and epigenetic marks of female rats subjected to a high-energy diet for four generations, demonstrated that transgenerational effects involving altered epigenetic marks at each generation were induced (at least partly) de novo[ 145].

We predicted accumulation of dcSAM induced hypomethylation of cystine residues of CpG islands and altered methylation marks of lysine residues of histone tails.

All differentially expressed GTPase-regulating genes had altered H3K4me3 marks, suggesting that the transcription of genes was mediated via epigenetic modifications of histones.