Sentence examples for alter its target from inspiring English sources

Antibiotic resistance can be acquired by a bacterium in two ways: Antibiotic resistance can be obtained by acquisition, via horizontal gene transfer, of antibiotic resistance genes that deactivate the antibiotic, prevent its entrance into the cell, alter its target, or remove it from the cell (Schmieder and Edwards 2012 ).

However, the fact that the lymph node mannose receptor binding of 3 can be diluted with unlabeled Lymphoseek such that distal node flow-through is increased serves to illustrate an important trait of the dual probe, that the conjugation of targets to NHS ester 1 does not alter its target's desired diagnostic properties, in this case Lymphoseek's mannose receptor-specific targeting properties.

But Foreign Minister Emma Bonino, a former European commissioner, responded that Italy cannot alter its targets, a view repeated by a spokesman for the European Commission in Brussels.

After binding the corresponding smRNA sequence, they regulate gene expression by a repressor effect or by altering its target.

In comparison resistance to echinocandins is acquired by altering its target but there is little evidence so far to suggest that the other mechanisms are occurring.

Indeed the European commission has altered its targets downwards for first-generation biofuels since October 2012, indicating its preference for non-food sources of sugar for biofuel production (EurActiv.com 2012).

Interestingly, the addition of the aromatic domain to 5-NA alters its target specificity, making the resulting compound EerI a more specific inhibitor for ER homeostasis.

In the modified conformational state, CaM is likely to alter its affinity to different targets by increasing and decreasing its affinity to certain proteins.

This has clear effects on cell trafficking events in mpkCCD cells, which are mimicked by RNAi knock-down of PI5P4Kγ, and either this is because it is inhibiting the PI5P 4-kinase activity of PI5P4Kγ, or it is displacing the enzyme from its localization in intracellular vesicles and thus altering its ability to target other proteins to these vesicles.

Plausibly, a slight change in choice of molecules results in a significantly dissimilar analog of a drug while not altering its functioning on many targets.

First, expression levels of many miRNAs vary greatly between different cell types/tissues or disease states, and this affects the stoichiometry of the binding of the miRNA to the target, potentially altering its impact.