Sentence examples for alter internalization from inspiring English sources

Using standard binding assays with radiolabeled ligand and COS-7 cells, substitutions in the dileucine motif or deletion of tyrosine residues in the G-CSFR did not alter internalization.

However, DM1 conjugation does not alter the internalization of anti-CD19 antibody (data not shown), whereas ricin conjugation to another anti-CD19 antibody increases its internalization, possibly via toxin dimerization and CD19 cross-linking (Goulet et al, 1997).

The binding of a ligand can either support or inhibit the interaction between the cytoplasmic tail of PSMA with clathrin and the clathrin adaptor protein-2 complex and thus alter the internalization efficiency [26, 27].

2. The methyl-lysine-recognizing Agenet domains of FMRP may still needed for its neuronal function, though Alpatov et al. have elucidated that the replication stress defective FMRP mutants, which abolish its methylated histone binding function, do not alter AMPAR internalization.

These results suggest that loss of either tyrosine residue at position 729 or 764 does not alter ligand/receptor internalization.

Stimulation of TGFβR signalling (Fig 5) and altered EGFR internalization and signalling (Fig S7) by AnxA1-RNAi did not affect the respective EMT.

Furthermore, specific mutations can radically alter superactivation or internalization without affecting the efficacy of acute Gi signaling.

Furthermore, and in agreement with the finding of altered post-internalization trafficking of MOP/DOP receptors, Milan-Lobo and Whistler reported that an internalized MOP/DOP receptor was handled differently from an internalized MOP receptor, tending towards degradation (Milan-Lobo and Whistler, 2011).

This agent did not alter bacterial binding or internalization (not shown).

Altering the CysLT1R internalization process at either the clathrin or the arrestin-3 stage led to disruption of LTD4-induced Erk1/2 activation and up-regulation of COX-2 mRNA levels.

The macrophages treated with CTB also showed altered adhesion and internalization indices).