The phrase "alter in the course of" is correct and usable in written English.
It can be used to describe changes that occur during a process or over time.
Example: "The project may alter in the course of its development as new information becomes available."
Alternatives: "change during" or "modify throughout".
We suggest that biologic behaviors of myeloma cells could be altered in the course of clonal expansion and this alteration would contribute to the chemotherapeutic resistance.
But something has altered in the course of a century or so.
PERT's latest annual report states the money was repaid in 2016 "after mutual agreement that the project has materially altered in the course of its execution".
We find that while postnatal growth further accentuates the differences in facial features between Neanderthals and modern humans, those features that have been suggested to link ATD6-69's morphology to modern humans would not have been significantly altered in the course of subsequent development.
However, as Zuckerman explained in his first report, this broad physio-psychological investigative remit was altered in the course of the initial experiments by what he described as 'unexpected findings leading to important conclusions'.
Cardiac death is a consequence of a complex interaction between the autonomic nervous system, a myocardial substrate altered in the course of disease processes, and myocardial vulnerability leading to arrhythmogenic or ischemic response.
Cardiovascular response to any stress (which may include air pollution) is a consequence of a complex interplay between the autonomic nervous system governing centrally mediated control of the cardiovascular system, a myocardial substrate (current state of the myocardium) altered in the course of disease processes, and myocardial vulnerability leading to arrhythmogenic or ischemic response.
In the light of the above, the current study aimed at determining whether the expression of VEGF, Flt-1, and Flk-1 and respective mRNAs of cerebellar neurons is altered in the course of BBB impairment caused by PNV in rats.
Indeed, the functional consequences of the age-related decline in neurogenesis have been examined only in relation to this function, known to be altered in the course of aging (Stevens & Cain, 1987; Grady & Craik, 2000; Hulshoff Pol et al., 2000; Kaneda et al., 2000).
Because cardiac death is a consequence of a complex interaction between the autonomic nervous system, a myocardial substrate altered in the course of disease processes, and myocardial vulnerability leading to arrhythmogenic or ischemic response, the presence of a single cardiac alteration is usually not sufficient to trigger cardiac death (Zareba et al. 2001).
