The phrase "alter highly" is not correct and does not convey a clear meaning in written English.
It is unclear what is intended by this phrase, as "alter" typically means to change something, while "highly" is an adverb that modifies an adjective or verb, but does not logically connect with "alter."
Example: "The results of the experiment did not alter highly, remaining consistent throughout the trials."
Alternatives: "significantly change" or "greatly modify."
Here, we have shown that a variety of mutations, designed to disrupt individually three pseudoknot (PK) structures and alter highly conserved nucleotides among the CrPV-like viruses, inhibit IGR IRES-mediated translation.
Interestingly, however these mutations alter highly conserved amino acids present in all Rab GTPases, suggesting that they are critical to the function of these small GTPases.
These changes are in the central intervening region of Keap1 and alter highly conserved amino acids.
In silico analyses revealed that all of the functionally characterized human Cx50 missense mutations alter highly conserved residues (Supplemental Figure 1; multiple sequence alignment provided as supplementary text).
All known mutations in CMT2B patients alter highly conserved amino acids in Rab7 and cause pathology in heterozygosity (Kwon et al., 1995; Verhoeven et al., 2003; Houlden et al., 2004; Meggouh et al., 2006).
SIFT Ng and Henikoff, 2006 and AlignGV-GD Tavtigian et al., 2006, for example, use multiple alignments to assay conservation levels of novel amino acid changing variants with the underlying assumption that sequence variants, which alter highly conserved positions in protein sequences are a priori more likely to be damaging.
Of note, the tumors without AKT1 in-frame duplications often had two or more point mutations altering highly conserved residues.
Interestingly, the non-synonymous changes in haplogroups J1 and N1b1 altered highly conserved amino-acid positions in OXPHOS complex I, implying that they possibly affect the activity of this complex [ 40].
The treated animals were sacrificed and the samples were analyzed 1) with 5 months - when first plaques and early dendrite degeneration can be identified in APP 23 mice - to detect protective effects and 2) with 11 months to clarify whether β1 antibody treatment allows recovery of altered highly ramified commissural neurons after a 4-month-treatment period.
In summary, pro-inflammatory cytokines might alter the highly selective barrier permeability of brain endothelial cells by establishing a new pattern of gene expression.
These tests are not redundant but rather complementary, because a given mutation may alter a highly conserved position yet did not radically change the physical chemical properties of the amino acid, and vice versa.
