The phrase "alter gene models" is correct and usable in written English.
It can be used in contexts related to genetics, bioinformatics, or computational biology when discussing modifications to genetic representations or simulations.
Example: "Researchers aim to alter gene models to better understand the effects of mutations on protein function."
Alternatives: "modify gene models" or "adjust gene models".
This proved difficult because: 1) it was unknown if a gene prediction was affected by a single SNP or multiple SNPs; 2) there were often many SNPs close to and within the altered gene model; and 3) many of the altered gene predictions did not have SNPs in obviously functional sites (e.g. a stop codon).
Pharmacologically active substances can alter gene expression, but a predictive model for hepatotoxicity should not confuse a substance with a desired pharmacologic effect with an unwanted toxic outcome.
These drugs can induce apoptosis, alter gene expression, and reverse therapy resistance in preclinical models.
In this model, the flanking DNA (from ES cells) contains polymorphisms that alter gene expression relative to the genetic background of the backcrossed mice.
Li et al. propose a new model for how chromatin remodelers can move nucleosomes and regulate transcription factors to alter gene activity.
Lifestyle can alter gene expression; we can nurture nature.
More provocative is evidence from studies in early stage prostate cancer that lifestyle factors can alter gene expression -- down-regulating cancer promoter genes, up-regulating cancer suppressor genes.
Biological Process annotation table for significantly altered genes in Model 7 obtained using ConsensusPathDB.
Our genetically engineered promoter may be useful for cell-type-specific gene targeting as well as for generating in vivo animal models with altered gene expression in a specific cell type.
A key finding in this study was that at a concentration as low as 22.5 μg/ml of PE-NPs, we measured altered gene expression in the 3-D model.
