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Mutant DMPK transcripts are toxic and alter gene expression at several levels.
An efficient and rapid way to alter gene expression is via regulation of mRNAs already transcribed.
In addition, this pattern of METH injections can alter gene expression in the dorsal striatum.
Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design.
Fluid forces can cause cultured cardiac cells to alter gene expression patterns and rearrange their cytoskeleton.
Classic "position-effect" experiments repositioned genes near telomeres to demonstrate that the epigenetic landscape can dramatically alter gene expression.
These compounds are able to compete with natural substrates, such as specific transcription factors, and alter gene expression.
The nonclinical γ-secretase inactive PS1-D257A mutation did not alter gene expression in either cell line.
Many non-coding genetic variants within risk-associated loci alter gene expression by modulating the activity of cis-regulatory elements.
When the signal molecules accumulate a threshold, the communicating microbes begin to alter gene expression, and therefore behavior, in response (Waters and Bassler 2005).
The above examples use AOs to alter gene expression, either directly or via competitive binding to receptors, to change disease progression.
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