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Although dimethyl sulfoxide (Me2SO) is generally regarded as a safe cryoprotectant, even low levels may alter function of repopulating cells.
In the zebrafish, MED12 defects cause maldevelopment of vertebrate embryonic structures such as the neural crest, which would alter function of the autonomic and peripheral nervous systems; and they also cause malformations of cell types serving as precursors to cartilage and bone, such as osteocytes.
Our findings emphasize that mutations which alter function of the MAPK pathway play an important role in ovarian cancer [15].
Surgical interventions at the shoulder may alter function of the shoulder complex.
These interactions can alter function of the substrate, a property known as HSP-mediated activity control.
Other aberrations than deletions/mutations of TP53 gene that can alter function of p53 pathway have been described.
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Alternatively, ATX or cytokines produced by the transgenic epithelial cells could alter functions of the stroma, which in turn contributes to the tumourigenic process.
This may be an essential factor in the triggering of attacks or may reflect generally altered function of central autonomic command.
Therefore, altered function of the limbic system appears to produce psychiatric disorders as well as osmophobia, and finally can provoke suicidality.
The increased fecundity was actualized by decreased interbirth interval and a longer reproductive period (greater age at last birth); the proximate (molecular) mechanisms relating altered function of BRCA1/2 to increased fecundity remain unclear.
As a consequence, altered function of the aPFC could have important ramifications for decision-making capability in drug abusers.
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