For example, the "Haddon matrix" emphasizes more proximal determinants of road injuries without assuming that national income is required to alter these determinants.
Similarly, the effects of critical illness, pre-existing chronic disease and pharmacotherapy can unpredictably alter physiological determinants of fluid responsiveness.
Health Impact Assessment (HIA) involves assessing how proposals may alter the determinants of health prior to implementation and recommends changes to enhance positive and mitigate negative impacts.
In the current study, we sought to define the determinants of inhibited PRE-dependent HIV-1 Gag assembly and budding in human cells and to test whether altering these determinants can alleviate this block.
[ 1- 3] Malignant transformation is associated with abnormal glycosylation, resulting in expression of altered carbohydrate determinants, such as the Sialyl Lewis x (sLex) antigen.
Malignant transformation of tumour cells is associated with abnormal glycosylation, resulting in expression of altered carbohydrate determinants including the expression of sLex and sLea antigens [ 4, 9, 12].
We next sought to understand how each historical amino acid change in the RH altered the determinants of binding within the RE.
To find out if neoadjuvant therapy could alter tumor response determinants that might affect tumor sensitivity to the treatment, we investigated intratumoral expressions of genes associated with chemosensitivity, radiosensitivity, or both before and after radiochemotherapy.
Similarly, protein crosslinking during tissue fixation may alter the antigenic determinants, whereas antigen retrieval techniques may 'unmask' unrelated antigens (Heyderman et al, 1989).
Against this background, the 1990s saw renewed calls for a 'paradigm shift' within public health, towards approaches that sought not only to persuade people to behave in more health-enhancing ways, but also to alter the contextual determinants of health related behaviours, both in terms of lifestyle behaviours as well as those linked to accessing health services and adhering to medical advice (4).
