Sentence examples for alter aggregation from inspiring English sources

In vitro studies have shown that polyamines can alter aggregation of insoluble compounds associated with disease.

A mutagenesis approach to finding modulators of protein aggregation, which also used C. elegans strain AM141, reported just one locus at which mutations alter aggregation: an uncharacterized gene termed moag-4 (van Ham et al., 2010).

In contrast to previous studies, there were no significantly altered aggregation responses in long-term alcoholic patients.

It has been argued that the pathology observed in Tg mice harboring mutations in their APP, PSEN, and/or MAPT is different from that seen in human AD, probably due to the abnormally high expression levels and/or altered aggregation properties of Aβ and tau [ 13, 14, 41, 46].

Moreover, Aβ oligomers in the presence of Eu3+ were observed to form fibrils indistinguishable from fibrils formed in the absence of Eu3+, therefore, Eu3+ does not adversely affect the morphology of the assembling peptides or alter the aggregation pathway (Supplementary Fig. 1).

These regions thus appear to alter the aggregation frequency and type of polyglutamine-induced aggregation.

We found that, akin to N1, the abovementioned synthetic peptides not only reduce the initial rate of Aβ fibrillization, but also alter the aggregation pathway of Aβ, inhibiting formation of protofibrillar oligomers and facilitating amorphous aggregation.

Because both Trpzip1 and Trpzip2 form parallel β-sheet aggregates, these results not only support the notion that Lys8 is an effective aggregation gatekeeper in Trpzip2 but also indicate that this non-natural lysine residue, which is strongly hydrophobic, can alter the aggregation pathway.

Size-exclusion chromatography analysis results showed that compound F27 can alter the aggregation of P10 proteins.

The distinct binding modes of chemical agents that alter αS aggregation highlight the potential of our models in inhibitor design.

Here, we investigate how these point mutations alter the aggregation of Aβ in the presence of supported lipid bilayers.