Sentence examples for alter active from inspiring English sources

Because the C-terminal tail has an important role in defining the size and shape of the active site cavity, a significant amino acid change at this position is likely to alter active site access and substrate selectivity, which is consistent with the substrate-dependent activity changes observed experimentally for the G286 variant.

Thermodynamic analysis shows that the free energy increment due to elastic deformation is insufficient to alter active dissolution rate remarkably.

Interestingly, at the NMJ, Teneurin perturbations reduced active zone and synaptic bouton numbers, but did not alter active zone density (TM, unpublished observations).

Given a previous proposal that AANAT can catalyze an alkyltransferase reaction in a conformationally altered active site relative to its acetyltransferase activity, it is possible that the two conformations of the bisubstrate analog observed crystallographically correspond to these alternative reaction pathways.

Here, we propose that the nuclease activity is regulated by movement of the β-hairpin, altering active site access and the orientation of catalytically essential residues.

The use of genetic engineering techniques to produce altered active enzymes has enhanced the use of enzymes as drugs.

Lower levels of expression of Importin-α2 are likely to be present elsewhere in the nervous system; the location of the intensely labeled neurons of the ventral nerve cord do not correspond to the motoneurons innervating muscles 6 and 7 where altered active zone density was observed in the mutants.

Therefore, it is possible that conformational changes involving the β-hairpin could influence the nuclease active site in addition to altering active site accessibility.

Mutations and residue insertions in other sites on the protein surface could bring about changes in protein interactions or changes in oligomerization state, again altering active site geometries.

This could be due to loss of an interaction with a lumenal region of PS1, thus altering active site conformation, or the fact that these residues normally block the entry of the substrate into the active site.

Because of their multiyear life spans, temperate perennial horticultural and forestry plants have an adaptive mechanism that alters active growth and vegetative dormancy in accord with seasonal climate changes.