Sentence examples for alt pathway from inspiring English sources

The precise molecular functions of Zscan4 in the possible ALT pathway in PSCs are still unclear.

Whether the ATRX/DAXX complex contributes to telomere regulation through the ALT pathway in ESCs needs further investigation.

At the embryo stage, telomeres are effectively elongated by a possible alternative lengthening of telomeres (ALT) pathway from zygote to blastocyst.

When Terc-deleted ESCs went through crisis after multiple passages, survived ESCs were found to use ALT pathway to maintain telomeres (Niida et al., 2000).

Loss of ATRX or DAXX leads to an increased DNA damage response, activation of the alternative lengthening of telomeres (ALT) pathway, and genomic instability (Dyer et al., 2017).

While 85%90%% of human cancers extend telomeres through the upregulation of telomerase activity, 10%15%% of cancers use the ALT pathway, a process that appears dependent on homologous recombination (Bryan et al., 1997; Shay and Bacchetti, 1997).

A 5' end invaded D-loop cannot be extended by a polymerase to complete the next steps of HR repair of replication forks, SDSA, or the ALT pathways [6], [11].

Second, if the Rad51 mediated D-loop formation is incomplete such that the 3' end is not fully paired with the template strand, it cannot be extended by a polymerase in the next steps of HR replication restart, SDSA or ALT pathways.

However, in ∼10% of human cancers telomeres are maintained through telomerase-independent alternative lengthening of telomeres (ALT) pathways.

Activations of the h TERT or ALT pathways are obligate for senescence bypass and for neoplastic transformation of normal cells (Newbold, 2002).

However, a potential pitfall of this approach is that blocking telomerase may lead to the activation of alternative telomere maintenance (ALT) pathways or may require an intact p53 response.