Exact(3)
Mean AST and ALT day 5 levels were 42 and 82 IU/l in recipients of IP livers compared with 79 and 247 IU/l in recipients of non-IP livers (P<0.05 and P<0.01 for AST and ALT day 5 levels, respectively).
AST and ALT day 5 levels were 139 and 423 IU/l in patients receiving steatotic grafts and 79 and 247 IU/l in patients receiving non-steatotic grafts (Table 4).
Mean AST and ALT day 5 levels were lower, but not significantly, in IP graft recipients compared with non-IP graft recipients (55 and 222 IU/l versus 139 and 423 IU/l, respectively).
Similar(57)
Significant differences between patients who developed sepsis during this period (9 patients) and SIRS were found in ALT on Day 1, in AST on Days 1 4, in PCT on Days 2 6; in CRP on Days 3 6; in IL-6 on Days 2 5; in leucocytes on Days 2, 3 and 6; and in D-dimers on Days 2 and 4. Significance values ranged from p < 0.0001 to p < 0.05.
At DL-2, one patient experienced grade 4 elevation of AST and grade 3 elevation of ALT on day 36 of cycle 1, which was resolved after permanent discontinuation of treatment.
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Figure 1 shows serum ALT levels on day 14 after initiation of treatment with co-trimoxazole.
IP significantly decreased both AST and ALT peak and day 5 levels in non-steatotic allografts recipients.
One of the two patients experienced a DLT, consisting on grade 3 ALT elevation on day +8.
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