The phrase "also with a substantial" is correct and usable in written English.
It can be used when adding additional information that emphasizes the significance or size of something in a context.
Example: "The project was successful, also with a substantial increase in revenue."
Alternatives: "along with a significant" or "in addition to a considerable".
He also won the points competition as the most consistent high finisher, also with a substantial lead over Scarponi in second place, and Vincenzo Nibali completed the podium.
The Ilizarov procedure is, however, associated with a high union rate, and also with a substantial refracture rate.
When it was over, the Giants (2-1) had not just survived the final scare, they had also escaped with a substantial victory over a skilled opponent.
The transition to permanent residence is also associated with a substantial increase in earnings for the OCI group.
Augmentation with lithium or second generation antipsychotics is an established practice in non-responders to antidepressant monotherapy, but is also associated with a substantial non-response rate and with non-tolerance.
Furthermore, a life that not only avoids repetition but also ends with a substantial amount of meaningful parts seems to have more meaning overall than one that has the same amount of meaningful parts but ends with few or none of them (Kamm 2003, 210 14).
The research tells the same story: A study published in April by researchers at Boston Medical Center and Harvard Medical School showed that while a decreased supply of prescription opioids led to a reduction in related overdoses, it also intersected with a substantial spike in heroin overdose deaths.
CTA use was also associated with a substantial referral rate increase of 47% among endocrinologists.
However, this increase in frequency was also associated with a substantial increase in overdiagnosis.
In addition to longer administration time, ZA infusion was also associated with a substantial time burden for healthcare providers.
Omphalocele is also associated with a substantial risk of infant morbidity and mortality, which is a severe disadvantage to the short- and long-term life of affected newborns.
