The phrase "also substantial changes in" is correct and usable in written English.
It can be used when discussing modifications or alterations that are significant in nature, often in a context of analysis or reporting.
Example: "The report highlights not only the financial losses but also substantial changes in the company's management structure."
Alternatives: "significant alterations in" or "major modifications in".
Furthermore, there are also substantial changes in the expression levels of the seven genes of interest and TL following a single mild injury in this brain region.
There were also substantial changes in the major integron, attributed to gain of individual cassettes including copying from within, or loss of blocks of cassettes.
Also substantial changes in epidemiology on HIV/AIDS mortality existed as mortality and also years of life loss due to opportunistic infections had significantly reduced in 2004 both men and women, after the introduction of universal ART in 2001.
Long-term economic mobility also produced substantial changes in partisanship.
Along with the climatic shifts documented by the paleosols there also are substantial changes in alluvial architecture and paleotopography.
Likewise, areas of declining suitability for rainfed agriculture, notably Europe and the southern portion of the U.S. Great Plains, may also experience substantial changes in ecosystem structure and potentially enhanced erosion and dust production as a result of crop failures.
Climate may also cause substantial changes in fish phenology.
It also incurs substantial changes in their basal gene expression program contributing to their abnormal distribution in the body.
Also, no substantial changes in cell-to-cell variability in total amounts and cytoplasmic levels of the two proteins were observed (change in CV<20%) (Figure S3C, D).
There may also be substantial changes in sleep length by season.
There were also less substantial changes in both genetic differentiation and genetic diversity at narrow corridor widths.
