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Recently, a systematic review also reported that substantial methodological and clinical heterogeneity was found among the studies in this issue.
The study also reported that substantial costs were incurred because of the time and transport required to access treatment, even though 70% of patients included in the study were living within an hour's walking distance of the clinic [ 27].
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It was also reported that a substantial proportion of patients on anastrozole fail to adhere to the recommended treatment after the first year.
The special counsel also reported that Flynn had provided "substantial assistance" in a separate criminal investigation whose details were completely redacted, and had assisted with a third matter that was not described at all.
Susanne Craig also reported that "a number of senior officers received substantial distributions from employee funds in 2011".
The Telegraph also reported that interviews with five members of Sir Philip's staff revealed that "substantial sums" had been paid in return for legal commitments not to discuss their alleged experiences.
It has also been reported that substantial weight loss reduces fibrinogen levels more effectively than modest weight reduction [ 53].
The NAS also reported that there were savings in tax dollars by ending criminal enforcement against marijuana possession noting that states that decriminalized "have led to substantial savings in states that have repealed laws that prohibit use".
Nevertheless pre-license trainings in IPE are very scarce in Germany [ 15, 16] and international reviews also report that a substantial amount of IPE occurs in CME rather than in a pre-license context [ 6, 17].
However, substantial proportions also report that they would be bored not working (31%); that they want to feel productive, useful, and helpful (18%); that they like to interact with people (13%); and that they have jobs that are fun (15%).
Subsequent studies, however, reported that substantial hypoglycaemia (blood glucose < 2.2 mmol/l) occurred frequently with intensive insulin therapy, and hypoglycaemia is also associated with adverse outcomes [ 16].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com