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The phrase "also no substantial changes" is correct and usable in written English.
It can be used when indicating that there have been no significant modifications or alterations in a particular context.
Example: "After reviewing the report, I can confirm that there are also no substantial changes to the original plan."
Alternatives: "no significant changes either" or "also no major alterations".
Exact(1)
Also, no substantial changes in cell-to-cell variability in total amounts and cytoplasmic levels of the two proteins were observed (change in CV<20%) (Figure S3C, D).
Similar(59)
The other sensitivity analyses also showed no substantial changes in the results (data not shown).
Thereafter there were no substantial changes.
"There are no substantial changes here," he said.
The pieces have been lightly edited, he tells us, and no substantial changes have been made.
Today, Mr. Weinstein and Mr. Ayoade say that no substantial changes were made.
There were no substantial changes in the results.
One: there were no substantial changes.
There have been no substantial changes.
No substantial changes were observed (data not shown).
We observed no substantial changes in incidence rates over time.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com