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The abnormal expression of miRNAs has been also linked to various disease pathologies [ 7, 8].

Prenatal exposure to tobacco smoke is also linked to various health, behavioral, and cognitive impairments (see Weitzman et al. 2002 for review).

However, aberrant DNA methylation is not limited to cancer cells; abnormal DNMT expression is also linked to various diseases including depression, anxiety disorder, dementia, autism, cardiovascular diseases, obesity and type 2 diabetes [ 25– 30].

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In addition to these RNA-binding domains the OST-HTH is also linked to several protein-protein interaction domains in various eukaryotes.

Apart from neurological disorders PUFA deficiency has also been linked to various cardiovascular, cerebrovascular, autoimmune diseases and cancers [ 4]. ω-3 fatty acids are also known for their anti-inflammatory properties [ 5].

Notably gamma oscillations (>30 Hz) are prominent in neocortex during attention [8], sensory processing [9, 10], or motor control tasks [11], together with slower rhythms in the theta (3 8 Hz) or delta (1 3 Hz) range that have also been linked to various aspects of cognitive processes like working memory or the transmission of sensory and motor signals.

Genes associated with disease development have also been linked to various stress responses.

Abnormal AS events have also been linked to various diseases [ 12- 15].

L 3)mbt has also been linked to various myeloid haemopoietic disorders (Boccuni et al., 2003) and is important for DNA replication and genomic stability (Gurvich et al., 2010).

Other known significant miRNAs of this signature are hsa-miR-155 and hsa-miR-622, which were also linked to enhanced tumorigenesis in various cancer types besides breast cancer [ 54, 55].

ICH is also linked to amyloid angiopathy, brain tumors and various vascular malformations (e.g. aneurysms, ateriovenous malformations, cerebral cavernous malformations) [ 7] (Table  1).

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