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Integrins are involved also in progression of the malignant phenotype.
Given these findings, it appears that the function of the APC/C is not only important in driving mitosis but also in progression of cells through G1 into the S-phase.
In addition, we found that the risk of BC associated with the GLO1 E allele significantly tended to increase according to tumour stage, thus suggesting a possible role of this polymorphism, not only in the development of this neoplasia but also in progression of local to advanced BC.
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The aim of this study was to investigate whether the alterations in DNA methylation of CXCL12 are also involved in progression of periodontitis in combination with diabetes, as these chronic inflammatory conditions are strongly interrelated.
Age-related changes not only are seen in old wt rats, but also participate in progression of reactive gliosis in tgHD rats.
Acidic pH has also been implicated in progression of cultured human melanoma cells, which were found to have increased invasiveness through Matrigel following acidic culture conditions (Martinez-Zaguilan et al, 1996).
Clinicians are of course interested in the general disease progression, but also in the progression of a separate component, such as mucus plugging, atelectasis or consolidation since treatment then can be focused on a specific pathology with a specific therapy.
The contemporary patterns are thus indistinguishable from historical ones as they also consist in progressions of the most widely distributed haplotypes.
Our data demonstrate that the microenvironment of lactation may also play a role in progression of PABC.
The receptor tyrosine kinase insulin like growth factor-1 receptor (IGF-1R) and its ligands, IGF-1 and IGF-2, are essential for cell growth and development [ 6] but also in the progression of various types of cancer, including HCC [ 7- 10].
Similarly, a study in the USA has also reported no significant differences in progression of diabetic kidney disease between the Black and White populations with equivalent diabetic control.
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