Findings from published studies are conflicting, but three recent analyses provide support for the Yale estimate, and more papers in the pipeline are also documenting a significant reduction in numbers of those who would qualify under the new criteria.
Interestingly, we also documented a significant increase in cortical osteocyte apoptosis and reduced sclerostin production.
We also documented a significant response to bronchodilator in 910 (11%) of participants including 33% of those with obstruction, 56% with a mixed pattern, and 18% of those with a low FVC.
Working with a human physiology course for undergraduate nonmajors, Pelaez (2002) also documented a significant increase in exam scores in response to written peer-graded exercises completed during class.
25 This Malawi study also documented a significant reduction in incidence of LTFU and a higher death rate in health centers when compared with hospitals, similar to our findings.
69, 70 Okanurak and others also documented a significant difference in cost of illness between a large referral center and provincial or community hospitals, although only three facilities were included in the study.
The study also documented a significant gene-environment interaction between eNOS intron 4 aa genotype and the habit of alcohol consumption for the risk of hypertension in the study population.
Colino et al. (2005) also documented a significant reduction in HbA1c levels following 6 months' therapy in 80 patients aged 2 to 19 years with type 1 diabetes treated with insulin glargine plus short-acting (regular human) insulin or a rapid-acting analog to provide mealtime cover.
Some reports have raised concerns about the observation of higher vancomycin MICs in isolates of patients with MRSA bacteraemia who had received vancomycin within the last 30 days [ 10, 11], and other authors have also documented a significant risk for treatment failure and a higher mortality with increasing vancomycin MIC, even if MICs are in the susceptible range [ 12, 13].
It also documents a scare with lymphoma.
